A complete map of the human immunoglobulin V H locus on hromosome 14 has recently
been constructed. The locus is 1100kb in length and contains 51 functional V H segments …

Inflammasomes are large, multimeric protein complexes that link the sensing of microbial
products and metabolic stress to the proteolytic processing of prointerleukin (pro-IL)-1β to its …

Recent evidence suggests a role for natural killer (NK) cells in the control of multiple myeloma.
We show that expression of the NK cell receptor DNAM-1 (CD226) is reduced on CD56 …

Background The NLRP3-inflammasome, implicated in the pathogenesis of several
inflammatory disorders, has been analysed in rheumatoid arthritis (RA). Methods Relative gene …

Immune evasion is now recognized as a key feature of cancer progression. In animal models,
the activity of cytotoxic lymphocytes is suppressed in the tumour microenvironment by the …

THE expression of immunoglobulin heavy-chain (IgH) genes is generally thought to be
regulated by the combination of the VH promoter with the enhancer element which is located in …

We have produced mice that carry the human Ig heavy (IgH) and both κ and λ light chain
transloci in a background in which the endogenous IgH and κ loci have been inactivated. The B …

We have previously described a strategy for integrating selectable marker genes into yeast
artificial chromosomes (YACs) to facilitate their transfer into embryonic stem (ES) cells. Here …

This paper gives an overview of progress made by the ISPE PQLI initiative - a global
industry-led initiative aimed at facilitating the implementation of ICH Q8, Q9, and ultimately Q10 …

Abstract Analysis of the telomeric region of chromosome 14q has enabled us to complete a
map of the immunoglobulin V H locus which accounts for almost all V H segments known to …